Zocor (simvastatin)." Side effects reported by some people include muscle pain and digestive problems. "Product Information. Available for Android and iOS devices. Arch Intern Med 152 (1992): 1093, 55. Am J Med 94 (1993): 109-10, 31. Br J Rheumatol 33 (1994): 199, 8. How Long Does Coronavirus Live On Surfaces? Along with its needed effects, rosuvastatin may cause some unwanted effects. Plosker GL, Mctavish D "Simvastatin - a reappraisal of its pharmacology and therapeutic efficacy in hypercholesterolaemia." Along with its needed effects, simvastatin may cause some unwanted effects. Chagnon JP, Cerf M "Simvastatin-induced protein-losing enteropathy." Diarrhea 6. Gonyeau MJ "Statins and osteoporosis: a clinical review." "Summaries for patients. Diaczok BJ, Shali R "Statins unmasking a mitochondrial myopathy: a case report and proposed mechanism of disease." Newman TB, Hulley SB "Carcinogenicity of lipid-lowering drugs." Br J Rheumatol 32 (1993): 647-8, 11. Arch Intern Med 156 (1996): 2085-92, 12. Sundram F, Roberts P, Kennedy B, Pavord S "Thrombotic thrombocytopenic purpura associated with statin treatment." Am J Med 87 (1989): s44-6, 30. Kidney Int 56 (1999): s117-21, 2. JAMA 292 (2004): 2585-90, 13. Rhabdomyolysis can cause severe muscle pain, liver damage, kidney failure and death. Adverse Drug Reactions Advisory Committee (ADRAC) and the Adverse Drug Reactions Unit of the TGA "Australian Adverse Drug Reactions Bulletin. JAMA 275 (1996): 55-60. Muscle abnormalities in four patients taking statins to treat unfavorable cholesterol levels." Pharmacotherapy 26 (2006): 414-22, 42. Nephron 89 (2001): 117-8, 37. Katznelson S "Effect of HMG-CoA reductase inhibitors on chronic allograft rejection." Krasovec M, Elsner P, Burg G "Generalized eczematous skin rash possibly due to HMG-CoA reductase inhibitors." Feldmann R, Mainetti C, Saurat JH "Skin lesions due to treatment with simvastatin (Zocor)." J Intern Med 240 (1996): 403-4. South Med J 98 (2005): 827-9, 35. ChoquetKastylevsky G, Kanitakis J, Dumas V, Descotes J, Faure M, Claudy A "Eosinophilic fasciitis and simvastatin." Muscle Pain 4. [Ref], Frequency not reported: Elevations in creatine kinase, myopathy, dermatomyositis, arthralgia, tendon rupture, Postmarketing reports: Muscle cramps, myalgia, rhabdomyolysis[Ref], This drug causes dose-related myopathy which, in rare cases maybe severe and sometimes take the form of rhabdomyolysis with or without renal failure secondary to myoglobinuria; rarely fatalities have occurred. This pain can include soreness and/or weakness in the muscles. These side effects may go away during treatment as your body adjusts to the medicine. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Muscle pain is one of the most common side effects reported by people who take a statin. The more common side effects that can occur with simvastatin include: Am J Gastroenterol 87 (1992): 257. If experienced, these tend to have a Severe expression 1. Dermatology 186 (1993): 272, 54. Statins Side Effect #1: Muscle Pain. There have been rare postmarketing reports of hepatic failure. simvastatin (Zocor) Common side effects of all statins. Am J Med 108 (2000): 351-2, 10. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Applies to simvastatin: oral suspension, oral tablet. © 2005 - 2019 WebMD LLC. Ramdass MJ, Singh G, Andrews B "Simvastatin-induced bilateral leg compartment syndrome and myonecrosis associated with hypothyroidism." Check with your doctor immediately if any of the following side effects occur while taking simvastatin: Some side effects of simvastatin may occur that usually do not need medical attention. See below for a comprehensive list of adverse effects. Molden E, Andersson KS "Simvastatin-associated rhabdomyolysis after coadministration of macrolide antibiotics in two patients." Postgrad Med J 80 (2004): 551-2, 43. If experienced, these tend to have a Severe expression, If experienced, these tend to have a Less Severe expression. Dermatology 186 (1993): 248-52, 53. J Clin Endocrinol Metab 86 (2001): 4556-9, 34. Gas 8. Simvastatin oral tablet doesn’t drowsiness, but it can cause other side effects. Meier CR, Schlienger RG, Kraenzlin ME, Schlegel B, Jick H "HMG-CoA reductase inhibitors and the risk of fractures." WebMD does not provide medical advice, diagnosis or treatment. Arora R, Liebo M, Maldonado F "Statin-induced myopathy: the two faces of Janus." Constipation 5. It’s not uncommon for us to feel aches and pains in our muscles. Ann Pharmacother 36 (2002): 820-3, 26. The Principal Investigators." While statins are well tolerated by many individuals, certain patients are at an increased risk of developing side effects. J Cardiovasc Pharmacol 40 (2002): 163-71, 15. Postgrad Med J 83 (2007): 152-3, 25. Johnson JL, Loomis IB "A case of simvastatin-associated pancreatitis and review of statin-associated pancreatitis."